GATA2 mutation underlies hemophagocytic lymphohistiocytosis in an adult with primary cytomegalovirus infection. Issue 2 (February 2020)

• Record Type: Journal Article
• Authors: Suzuki, Tetsuya; Takaya, Saho; Kunimatsu, Junwa; Kutsuna, Satoshi; Hayakawa, Kayoko; Shibata, Hirofumi; Yasumi, Takahiro; Ohmagari, Norio
• Is Part Of: Journal of infection and chemotherapy. Volume 26:Issue 2(2020:Feb.)
• Page Start: 252
• Page End: 256
• Publication Date: 2020-02
• Subjects: GATA binding protein 2 -- Monocytopenia -- NK lymphocytopenia -- B lymphocytopenia -- Primary cytomegalovirus infection -- Hemophagcytic lymphohistiocytosis; Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2019.07.002
• Languages: English
• ISSNs: 1341-321X

Abstract

Abstract: We report a case of a 27-year old woman with persistent fever and pancytopenia who had multiple episodes of a hemophagocytic lymphohistiocytosis (HLH) like condition. The criterion for HLH was satisfied; primary cytomegalovirus (CMV) infection was identified as the cause. Further examination revealed a GATA binding protein 2 mutation. Reports of GATAs deficiency presenting with HLH after primary CMV infection is very limited. As early recognition and diagnosis will improve patients' outcomes, internists and infectious disease specialists should be aware of this disease.