Gastrointestinal Lymphomas: Immunohistologic Study of 23 Cases. Issue 6 (27th January 2016)

• Record Type: Journal Article
• Authors: Berger, Francoise; Coiffier, Bertrand; Bonneville, Carole; Scoazec, Jean-Yves; Magaud, Jean-Pierre; Bryon, Paul Andre
• Is Part Of: American journal of clinical pathology. Volume 88:Issue 6(1987)
• Page Start: 707
• Page End: 712
• Publication Date: 2016-01-27
• Subjects: Gastrointestinal lymphomas -- Immunohistology; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; 616.07
• DOI: 10.1093/ajcp/88.6.707
• Languages: English
• ISSNs: 0002-9173

Abstract

Abstract : Twenty-three primary gastrointestinal lymphomas were studied morphologically and immunologically on fresh frozen tissue, and on cell suspension for 16 of them. Polyclonal antibodies reactive with immunoglobulin chains and a panel of 16 monoclonal antibodies reactive with B- and T-cells, histiocytes, and epithelial cells were used. According to the Working Formulation, 5 cases were low grade, 12 intermediate grade, and 5 high grade; 1 case was an extramedullar plasmocytoma. Forty-seven percent were large cell lymphomas and 13% follicular lymphomas. There were 20 (86%) B-cell lymphomas and 2 T-cell lymphomas; one case lacked detectable markers for B-, T-, or histiocytic cells. Monoclonality was demonstrated in 13 out of the 20 B-cell lymphomas, whereas the other 7 expressed pan-B antigens. It is concluded that immunologic studies on frozen surgical material are of precise diagnostic value in gastrointestinal lymphomas, whereas fixed endoscopic biopsies only permit the distinction between lymphomas and undifferentiated carcinomas.