Synthesis and biological evaluation of FICZ analogues as agonists of aryl hydrocarbon receptor. Issue 5 (1st March 2020) - Wu, Hao
Graphical abstract: Abstract: The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor involved in multiple biological processes including immune cell differentiation, intestinal function and inflammation. Based on the scaffold of naturally occurring AhR ligand 6-formylindolo (3, 2- b ) carbazole (FICZ, 2 ), a series of analogues has been designed, synthesized and evaluated by cell-based assays. The structure-activity relationships study has successfully led to the discovery of compound 11e with extremely potent activity.