Effects of regional body temperature variation during asphyxial cardiac arrest on mortality and brain damage in a rat model. (January 2020)

• Record Type: Journal Article
• Authors: Kim, Yoon Sung; Cho, Jun Hwi; Shin, Myoung-cheol; Park, Yoonsoo; Park, Chan Woo; Tae, Hyun-Jin; Cho, Jeong Hwi; Kim, In-Shik; Lee, Tae-Kyeong; Park, Young Eun; Ahn, Ji Hyeon; Park, Joon Ha; Kim, Dae Won; Won, Moo-Ho; Lee, Jae-Chul
• Is Part Of: Journal of thermal biology. Volume 87(2019)
• Publication Date: 2020-01
• Subjects: Asphyxial cardiac arrest and cardiopulmonary resuscitation -- Ischemia -- Hypothermia -- Survival rate -- Neurological deficit -- Delayed neuronal death; Thermobiology -- Periodicals; Temperature -- Periodicals; Biology -- Periodicals; Thermobiologie -- Périodiques; Thermobiology; Periodicals; 571.46
• DOI: 10.1016/j.jtherbio.2019.102466
• Languages: English
• ISSNs: 0306-4565

Abstract

Abstract: To date, hypothermia has focused on improving rates of resuscitation to increase survival in patients sustaining cardiac arrest (CA). Towards this end, the role of body temperature in neuronal damage or death during CA needs to be determined. However, few studies have investigated the effect of regional temperature variation on survival rate and neurological outcomes. In this study, adult male rats (12 week-old) were used under the following four conditions: (i) whole-body normothermia (37 ± 0.5 °C) plus (+) no asphyxial CA, (ii) whole-body normothermia + CA, (iii) whole-body hypothermia (33 ± 0.5 °C)+CA, (iv) body hypothermia/brain normothermia + CA, and (v) brain hypothermia/body normothermia + CA. The survival rate after resuscitation was significantly elevated in groups exposed to whole-body hypothermia plus CA and body hypothermia/brain normothermia plus CA, but not in groups exposed to whole-body normothermia combined with CA and brain hypothermia/body normothermia plus CA. However, the group exposed to hypothermia/brain normothermia combined with CA exhibited higher neuroprotective effects against asphyxial CA injury, i.e. improved neurological deficit and neuronal death in the hippocampus compared with those involving whole-body normothermia combined with CA. In addition, neurological deficit and neuronal death in the group of rat exposed to brain hypothermia/body normothermia and CA were similar to those in the rats subjected to whole-body normothermia and CA. In brief, only brain hypothermia during CA was not associated with effective survival rate, neurological function or neuronal protection compared with those under body (but not brain) hypothermia during CA. Our present study suggests that regional temperature in patients during CA significantly affects the outcomes associated with survival rate and neurological recovery. Highlights: Regional temperature differently affects Survival rate after asphyxial cardiac arrest (CA). Survival rate after CA is lowest in rats with brain hypothermia during CA. Survival rate after CA is improved at least in rats with body hypothermia during CA. Neurological deficit and neuronal death are lowest in rats with brain hypothermia during CA. Deficit and neuronal death are improved at least in rats with body hypothermia during CA.