Circulating S100A8/A9 Levels Reflect Intraocular Inflammation in Uveitis Patients. (2nd January 2020)

• Record Type: Journal Article
• Authors: Wang, Yu-Qin; Dai, Xiao-Dan; Ran, Yun; Cao, Ying; Lan, Chun-Lin; Guan, Ji-Tian; Liu, Chang; Yang, Feng-Mei; Gan, Yi-Jing; Liu, Bai-Jing; Fang, Ai-Wu; Lin, Dan; Gong, Xian-Hui; Cui, Ren-Zhe; Jin, Zi-Bing; Qu, Jia; Lu, Fan; Chi, Zai-Long
• Is Part Of: Ocular immunology and inflammation. Volume 28:Number 1(2020)
• Page Start: 133
• Page End: 141
• Publication Date: 2020-01-02
• Subjects: Biomarker -- calprotectin -- ocular inflammation -- S100A8/A9 -- uveitis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2018.1538461
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: To investigate whether there is an association between circulating S100A8/A9 levels and uveitis activity. Methods: A total of 549 plasma samples were collected from uveitis patients and non-uveitic controls. Results: S100A8/A9 plasma levels were elevated in uveitis patients compared to non-uveitic controls ( P < 0.001). S100A8/A9 plasma levels in patients with active acute anterior uveitis (AAU) were significantly elevated and remarkably decreased in parallel with the severity of intraocular inflammation after corticosteroid treatment ( P < 0.001). S100A8/A9 plasma levels were also higher in AAU patients with ankylosing spondylitis (AS) than in patients without AS ( P = 0.02). S100A8/A9 plasma levels were significantly increased in uveitis patients with elevated C-reactive protein (CRP, P = 0.004) or erythrocyte sedimentation rates (ESR, P = 0.049) levels compared to uveitis patients with normal CRP or ESR values. Conclusion: Circulating S100A8/A9 might be a useful biomarker for the measurement of intraocular inflammation.