Anticancer drug delivery to cancer cells using alkyl amine-functionalized nanodiamond supraparticles. Issue 9 (28th August 2019)

• Record Type: Journal Article
• Authors: Yu, Yue; Yang, Xi; Liu, Ming; Nishikawa, Masahiro; Tei, Takahiro; Miyako, Eijiro
• Is Part Of: Nanoscale advances. Volume 1:Issue 9(2019)
• Page Start: 3406
• Page End: 3412
• Publication Date: 2019-08-28
• Subjects: 620.5
• DOI: 10.1039/c9na00453j
• Languages: English
• ISSNs: 2516-0230

Abstract

Abstract : Nanocarriers have attracted increasing interest due to their potential applications in anticancer drug delivery. Abstract : Nanocarriers have attracted increasing interest due to their potential applications in anticancer drug delivery. In particular, the ability of nanodiamonds (NDs) to spontaneously self-assemble into unique nano-structured architectures has been exploited in the development of nanocarriers. In this context, we synthesized functional supraparticles (SPs) by the self-assembly of alkyl amine-modified NDs for use in anticancer chemotherapy. The structural, physical, and physiological properties of these ND-SPs as well as their high biocompatibility were assessed using microscopic techniques and various characterization experiments. Finally, a model anticancer drug (CPT; camptothecin) was loaded into the ND-SPs to investigate their anticancer efficacy in vitro and in vivo . After incubation of CPT-loaded ND-SPs with cancer cells, a dramatic anticancer effect of ND-SPs was expressed, compared to CPT-loaded ordinary nanocarriers of polyethylene glycol-modified polymer micelles and conventional Intralipid® 20% emulsions containing CPT. Our results demonstrated that ND-SPs may serve as a nanomedicine with significant therapeutic potential.