Cobaltaelectro-catalyzed oxidative allene annulation by electro-removable hydrazides. Issue 9 (8th January 2020)

• Record Type: Journal Article
• Authors: Mei, Ruhuai; Fang, Xinyue; He, Liang; Sun, Junmei; Zou, Liang; Ma, Wenbo; Ackermann, Lutz
• Is Part Of: Chemical communications. Volume 56:Issue 9(2020)
• Page Start: 1393
• Page End: 1396
• Publication Date: 2020-01-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc09076b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A sustainable and highly efficient cobaltaelectro-catalyzed C–H/N–H functionalization with allenes was developed featuring electro-reductive hydrazide cleavage. Abstract : An efficient C–H/N–H functionalization with allenes was enabled via versatile electro-oxidative cobalt catalysis. Thus, electrochemical C–H activations were accomplished with high levels of chemoselectivity and regioselectivity in an operationally simple undivided cell setup. The user-friendly nature of this protocol was highlighted by excellent functional group tolerance, an electro-reductive removable hydrazide directing group and easy scalability. Experimental mechanistic studies were indicative of a facile BIES C–H cobaltation event.