Relationship between vitamin D status in pregnancy and the risk for preeclampsia: A nested case-control study. Issue 2 (February 2020)

• Record Type: Journal Article
• Authors: Benachi, Alexandra; Baptiste, Amandine; Taieb, Joëlle; Tsatsaris, Vassilis; Guibourdenche, Jean; Senat, Marie-Victoire; Haidar, Hazar; Jani, Jacques; Guizani, Meriem; Jouannic, Jean-Marie; Haguet, Marie-Clotilde; Winer, Norbert; Masson, Damien; Courbebaisse, Marie; Elie, Caroline; Souberbielle, Jean-Claude
• Is Part Of: Clinical nutrition. Volume 39:Issue 2(2020)
• Page Start: 440
• Page End: 446
• Publication Date: 2020-02
• Subjects: Vitamin D deficiency -- Preeclampsia -- Nested case-control study; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2019.02.015
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: Vitamin D is thought to be involved in the pathogenesis of preeclampsia. To evaluate the relationship between vitamin D insufficiency in the first trimester of pregnancy and preeclampsia. Methods: Nested case-control study (FEPED study) in type 3 obstetrical units. Pregnant women from 10 to 15 WA. For each patient with preeclampsia, 4 controls were selected from the cohort and matched by parity, skin color, maternal age, season and BMI. The main outcome measure was serum 25(OH)D status in the first trimester. Results: 83 cases of preeclampsia were matched with 319 controls. Mean 25(OH)D levels in the first trimester were 20.1 ± 9.3 ng/mL in cases and 22.3 ± 11.1 ng/mL in controls (p = 0.09). The risk for preeclampsia with 25(OH)D level ≥30 ng/mL in the first trimester was decreased, but did not achieve statistical significance (OR, 0.57; 95% CI, 0.30–1.01; p = 0.09). High 25(OH)D during the 3rd trimester was associated with a significantly decreased risk of preeclampsia (OR, 0.43; 95%CI, 0.23–0.80; p = 0.008). When women with 25(OH)D levels <30 ng/mL both in the first and 3rd trimesters ("low-low") were taken as references, OR for preeclampsia was 0.59 (95% CI, 0.31–1.14; p = 0.12) for "low-high" or "high-low" women and 0.34 (95% CI, 0.13–0.86; p = 0.02) for "high-high" women. Conclusions: No significant association between preeclampsia and vitamin D insufficiency in the first trimester was evidenced. However, women with vitamin D sufficiency during the 3rd trimester and both in the first and 3rd trimesters had a significantly lower risk of preeclampsia.