Circadian disruption and human health: A bidirectional relationship. (3rd January 2019)

• Record Type: Journal Article
• Authors: Abbott, Sabra M.; Malkani, Roneil G.; Zee, Phyllis C.
• Is Part Of: European journal of neuroscience. Volume 51:Number 1(2020)
• Page Start: 567
• Page End: 583
• Publication Date: 2019-01-03
• Subjects: chronotherapy -- melatonin -- neurodegenerative disease -- shift work; Nervous system -- Periodicals; 612.8
• DOI: 10.1111/ejn.14298
• Languages: English
• ISSNs: 0953-816X

Abstract

Abstract: Circadian rhythm disorders have been classically associated with disorders of abnormal timing of the sleep–wake cycle, however circadian dysfunction can play a role in a wide range of pathology, ranging from the increased risk for cardiometabolic disease and malignancy in shift workers, prompting the need for a new field focused on the larger concept of circadian medicine. The relationship between circadian disruption and human health is bidirectional, with changes in circadian amplitude often preceding the classical symptoms of neurodegenerative disorders. As our understanding of the importance of circadian dysfunction in disease grows, we need to develop better clinical techniques for identifying circadian rhythms and also develop circadian based strategies for disease management. Overall this review highlights the need to bring the concept of time to all aspects of medicine, emphasizing circadian medicine as a prime example of both personalized and precision medicine. Abstract : The relationship between circadian disruption and human health is bidirectional. Circadian dysfunction can either result from abnormal timing or decreased amplitude of circadian signals. This dysfunction is associated with an increased risk for neurodegenerative disease, cardiometabolic disease and malignancy. These disorders can in turn feedback and cause further circadian dysfunction. Further research is needed into the use of strategies to improve circadian health, in turn improving disease outcomes. This review highlights the importance of time across multiple aspects of medicine, and discusses the concept of a new field focused on these interactions: circadian medicine.