New Borrelidins from Onchidium sp. Associated Streptomyces olivaceus SCSIO LO13. Issue 1 (18th December 2019)

• Record Type: Journal Article
• Authors: Zhou, Zhenbin; Wu, Qiaoling; Xie, Qing; Ling, Chunyao; Zhang, Hua; Sun, Changli; Ju, Jianhua
• Is Part Of: Chemistry & biodiversity. Volume 17:Issue 1(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-12-18
• Subjects: Onchidium sp. derived actinomycete -- borrelidin family -- cytotoxicity -- antibacterial activity -- structure-activity relationships (SARs); Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201900560
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Borrelidins M−O (1 –3 ), along with four previously known family members (4 –7 ), were isolated from marine pulmonated mollusks Onchidium sp. associated Streptomyces olivaceus SCSIO LO13. The structures of 1 –3 were elucidated by extensive spectral analyses of HR‐ESI‐MS, 1D and 2D NMR data. In addition, the cytotoxic and antibacterial activities of 1 –7 were evaluated enabling us to propose some tentative structure‐activity relationships (SARs), especially those involving modifications at C(22) and the moieties at C(7) and C(8) of the borrelidin scaffold. Abstract :