Biomimetic Networks with Enhanced Photodynamic Antimicrobial Activity from Conjugated Polythiophene/Polyisocyanide Hybrid Hydrogels. (9th January 2020)

• Record Type: Journal Article
• Authors: Yuan, Hongbo; Zhan, Yong; Rowan, Alan E.; Xing, Chengfen; Kouwer, Paul H. J.
• Is Part Of: Angewandte Chemie. Volume 132:Number 7(2020)
• Page Start: 2742
• Page End: 2746
• Publication Date: 2020-01-09
• Subjects: Biomimetische Hydrogele -- Dehnungsversteifung -- Photodynamische antimikrobielle Chemotherapie -- Polyisocyanide -- Polythiophene; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201910979
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Hybrid biomimetic hydrogels with enhanced reactive oxygen species (ROS)‐generation efficiency under 600 nm light show high antibacterial activity. The hybrid gels are composed of helical tri(ethylene glycol)‐functionalized polyisocyanides (PICs) and a conformation‐sensitive conjugated polythiophene, poly(3‐(3′‐ N, N, N ‐triethylammonium‐1′‐propyloxy)‐4‐methyl‐2, 5‐thiophene chloride) (PMNT). The PIC polymer serves as a scaffold to trap and align the PMNT backbone into a highly ordered conformation, resulting in redshifted, new sharp bands in the absorption and fluorescence spectra. Similar to PIC, the hybrid closely mimics the mechanical properties of biological gels, such as collagen and fibrin, including the strain stiffening properties at low stresses. Moreover, the PMNT/PIC hybrids show much higher ROS production efficiency under red light than PMNT only, leading to an efficient photodynamic antimicrobial effect towards various pathogenic bacteria. Abstract : Dehnungsübungen : Hybride biomimetische Hydrogele mit erhöhter Bildung reaktiver Sauerstoffspezies (ROS) unter 600‐nm‐Bestrahlung zeigen antibakterielle Aktivität. Außerdem imitieren sie recht genau die mechanischen Eigenschaften biologischer Gele wie Collagen und Fibrin, darunter Dehnungsversteifung bei geringer mechanischer Spannung.