Para-Selective copper-catalyzed C(sp2)–H amidation/dimerization of anilides via a radical pathway. Issue 10 (13th January 2020)

• Record Type: Journal Article
• Authors: Viveki, Amol B.; Garad, Dnyaneshwar N.; Gonnade, Rajesh G.; Mhaske, Santosh B.
• Is Part Of: Chemical communications. Volume 56:Issue 10(2020)
• Page Start: 1565
• Page End: 1568
• Publication Date: 2020-01-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc09824k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A unique process for para -selective C–H functionalization leading to amidation/dimerization of anilide derivatives via a radical pathway has been demonstrated. Abstract : Copper-catalyzed amidation/dimerization of anilides via regioselective C(sp 2 )–H functionalization is achieved. The para -selective amidation is accomplished on the anilide aromatic ring via a radical pathway leading to C–N bond formation in the presence of ammonium persulfate as a radical source/oxidant for the copper catalyst. The developed protocol tolerates a wide range of anilide substrates. The regioselectivity is confirmed by single-crystal X-ray studies.