Phomeroids A and B: two novel cytotoxic meroterpenoids from the deep-sea-derived fungus Phomopsis tersa FS441. Issue 3 (9th January 2020)

• Record Type: Journal Article
• Authors: Chen, Shanchong; Liu, Zhaoming; Tan, Haibo; Chen, Yuchan; Li, Saini; Li, Haohua; Zhu, Shuang; Liu, Hongxin; Zhang, Weimin
• Is Part Of: Organic chemistry frontiers. Volume 7:Issue 3(2020)
• Page Start: 557
• Page End: 562
• Publication Date: 2020-01-09
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c9qo01365b
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Phomeroids A (1 ) and B (2 ), two novel meroterpenoids representing two types of skeletons, together with one known homologous analogue (3 ) were isolated from the deep-sea-derived fungus Phomopsis tersa FS441. Abstract : Phomeroids A (1 ) and B (2 ), two novel meroterpenoids representing two types of skeletons, together with one known homologous analogue (3 ) were isolated from the deep-sea-derived fungus Phomopsis tersa FS441. Phomeroid A is the first example of tropolonic sesquiterpenes consisting of a highly fused 6/6/11/6/5/5 ring system, while phomeroid B is the first example of meroterpenoids featuring an unusual 7/6/11/6-5 spiral core skeleton. All of them showed considerable cytotoxicity against the tested cell lines, and their biosynthetic pathways were also discussed.