Postoperative Antifungal Treatment of Pulmonary Cryptococcosis in Non-HIV-Infected and Non-Transplant-Recipient Patients: A Report of 110 Cases and Literature Review. (13th January 2020)

• Record Type: Journal Article
• Authors: Wei, Shuo; Su, Xin; Pan, Yun-hu; Zheng, Yuan-yuan; Dong, Xiao-wen; Hu, Xiao-hua; Wu, Fan; Shi, Yi
• Is Part Of: Open forum infectious diseases. Volume 7:Number 1(2020)
• Publication Date: 2020-01-13
• Subjects: antifungal therapy -- cryptococcal meningitis -- pulmonary cryptococcosis -- surgery; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofaa004
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Background: To explore the efficacy of postoperative antifungal treatment for preventing the recurrence of pulmonary cryptococcosis (PC) and occurrence of cryptococcal meningitis (CM), a retrospective study was conducted in 112 hospitalized PC patients with or without antifungal treatment following surgery. Methods: The treatment failure rate, PC recurrence rate, and CM incidence were compared. Additionally, the effectiveness of postoperative antifungal therapy was assessed by gathering and analyzing the published literature. Results: The failure rate ( P = .054) and recurrence rate ( P = .178) were similar in the 2 groups, but the incidence of CM was lower in the group that received postoperative antifungal treatment ( P = .039). Conclusions: This study did not show any difference in the PC recurrence rate or failure rate in the different treatment duration groups. Thus, a shorter antifungal treatment course of 2 months may be an optional treatment. In addition, upon review of the literature, no case of CM occurrence was reported among the 169 cases given postoperative antifungal treatment.