Reversible Bioadhesives Using Tannic Acid Primed Thermally‐Responsive Polymers. (20th November 2019)

• Record Type: Journal Article
• Authors: Li, Bin; Whalen, John J.; Humayun, Mark S.; Thompson, Mark E.
• Is Part Of: Advanced functional materials. Volume 30:Number 5(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-11-20
• Subjects: cohesive failure -- hydrogels -- responsive polymers -- reversible adhesives -- tannic acid; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201907478
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: A two‐layer approach is reported for the formation of a thermally triggered reversible adhesive, involving a thermally‐responsive polymer matrix coated on tannic acid‐pretreated substrates/tissues. Interfacial adhesion originates from strong molecular interactions of tannic acid with both the polymer matrix and the substrate/tissue. The reversibility is due to a temperature‐triggered phase transition of the polymer matrix, leading to cohesive failure. Depending on different gelation mechanisms, the polymer forms a highly cohesive gel or soft solid upon either warming or cooling, leading to a strong adhesion to the tissues at physiological temperatures. Detachment of the adhesive is triggered by a temperature‐induced compromise of cohesive strength of the polymer matrix, by the opposite gel‐to‐sol transition. This facile, low‐cost, and modular design offers a reversible adhesive platform which is useful for biomedical and industrial applications. Abstract : A two‐layer approach is reported for the formation of a thermally‐triggered reversible adhesive, involving a thermally‐responsive polymer matrix coated on tannic acid–pretreated substrate/tissue. The reversibility is due to a phase transition of the polymer matrix, leading to cohesive failure. The "bound state" of the adhesive gives strong and durable adhesion to the tissue at physiological temperatures of 22–37 °C.