Increased neural reactivity to emotional pictures in men with high hair testosterone concentrations. Issue 9 (11th September 2019)

• Record Type: Journal Article
• Authors: Klein, Sanja; Kruse, Onno; Tapia León, Isabell; Stalder, Tobias; Stark, Rudolf; Klucken, Tim
• Is Part Of: Social cognitive and affective neuroscience. Volume 14:Issue 9(2019)
• Page Start: 1009
• Page End: 1016
• Publication Date: 2019-09-11
• Subjects: fMRI -- emotion -- testosterone; Neurosciences -- Periodicals; Cognitive neuroscience -- Periodicals; Neuropsychology -- Periodicals; 612.8205
• DOI: 10.1093/scan/nsz067
• Languages: English
• ISSNs: 1749-5016

Abstract

Abstract: Testosterone has been linked to alterations in the activity of emotion neurocircuitry including amygdala, orbitofrontal cortex (OFC) and insula and diminished functional amygdala/prefrontal coupling. Such associations have only ever been studied using acute measures of testosterone, thus little is known about respective relationships with long-term testosterone secretion. Here, we examine associations between hair testosterone concentration (HTC), an index of long-term cumulative testosterone levels and neural reactivity during an emotional passive viewing task using functional magnetic resonance imaging (fMRI). Forty-six men viewed negative, positive and neutral pictures in the MRI. HTCs were assessed from 2 cm hair segments. The emotional paradigm elicited neural activation in the amygdala, insula and OFC. HTCs were associated with increased reactivity to negative pictures in the insula and increased reactivity to positive pictures in the OFC. We show an association of long-term testosterone levels with increased emotional reactivity in the brain. These results suggest a heightened emotional vigilance in individuals with high trait testosterone levels.