Accelerated Immunodeficiency-associated Vaccine-derived Poliovirus Serotype 3 Sequence Evolution Rate in an 11-week-old Boy With X-linked Agammaglobulinemia and Perinatal Human Immunodeficiency Virus Exposure. (14th May 2019)

• Record Type: Journal Article
• Authors: Jallow, Sabelle; Wilmshurst, Jo M; Howard, Wayne; Copelyn, Julie; Seakamela, Lerato; Chan, Koon-Wing; Sebunya, Robert; Sibiya, Rosinah; Du Plessis, Heleen; Jacobs, Charlene; Berkowitz, Natacha; Blumberg, Lucille; McCarthy, Kerrigan; Maseti, Elizabeth; Kamupira, Mercy; Dlamini, Nonhlanhla; Gumede, Nicksy; Diop, Ousmane M; Lau, Yu Lung; Moonsamy, Shelina; Eley, Brian; Suchard, Melinda
• Is Part Of: Clinical infectious diseases. Volume 70:Number 1(2020)
• Page Start: 132
• Page End: 135
• Publication Date: 2019-05-14
• Subjects: oral poliovirus vaccine -- acute flaccid paralysis -- X-linked agammaglobulinemia -- Bruton tyrosine kinase -- HIV-exposed but uninfected; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciz361
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses. We report immunodeficiency-associated vaccine-derived poliovirus serotype 3 in an 11-week-old boy with X-linked agammaglobulinemia. Unique characteristics of this case include early age of presentation, high viral evolutionary rate, and the child's perinatal exposure to human immunodeficiency virus.