440PAccuracy of risk scoring system to determine delayed chemotherapy induced nausea and vomiting (CINV) in cancer patients. (24th November 2019)

• Record Type: Journal Article
• Authors: Reddy, H; Maka, V V; D, A; Krishna Murthy, M; Mandepudi, A; Paibhavi, P R; K, S P; Vungarala, S
• Is Part Of: Annals of oncology. Volume 30(2019)Supplement 9
• Publication Date: 2019-11-24
• Subjects: Oncology -- Periodicals; 616.992
• DOI: 10.1093/annonc/mdz434.020
• Languages: English
• ISSNs: 0923-7534

Abstract

Abstract: Background: In this study the risk scoring algorithm is evaluated to see the ability of the scoring systems to accurately identify patients deemed to be high risk for CINV. Methods: Patients who were receiving first chemotherapy regime at our center were included in the study after due informed consenting and Ethics committee approval. Patients were followed for 5-days after chemotherapy by either in person questioning or telephone call. All patients received standard anti-emetic prophylaxis at discretion of treating physician. Before each cycle of chemotherapy, acute and delayed CINV scoring systems were used to stratify patients into low- and high-risk groups. Logistic regression modelling was then applied to compare the risk for grade 2 or greater CINV between patients considered to be at high and at low risk. The external validity of each system was also assessed using an area under the receiver operating characteristic curve (AUROC) analysis. Results: CINV outcomes data was collected from 128 patients during 356 cycles of chemotherapy. The incidence of delayed CINV was 76.4% respectively. Major predictors for CINV included younger patient age, earlier cycles of chemotherapy, previous history of morning sickness, and prior emetic episodes after chemotherapy. The delayed scoring system had good predictive accuracy when applied to the external validation sample (delayed—AUROC: 0.75; 95% confidence interval: 0.70 to 0.80). Patients identified by the scoring systems to be at high risk were 3.8 (p = 0.001) times more likely to develop grade 2 or greater delayed CINV. Conclusions: Our study demonstrates current Patient risk scoring systems are able to accurately identify patients at high risk for delayed CINV and can be used to augment current antiemetic regimes. Legal entity responsible for the study: Vinayak V Maka. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.