Programming DNA Nanoassembly for Enhanced Photodynamic Therapy. Issue 5 (9th December 2019)

• Record Type: Journal Article
• Authors: Pan, Min; Jiang, Qunying; Sun, Junlin; Xu, Zhen; Zhou, Yizhuo; Zhang, Li; Liu, Xiaoqing
• Is Part Of: Angewandte Chemie international edition. Volume 59:Issue 5(2020)
• Page Start: 1897
• Page End: 1905
• Publication Date: 2019-12-09
• Subjects: cancer therapy -- DNA nanotechnology -- nucleic acids -- photodynamic therapy -- self-assembly; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201912574
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Photodynamic therapy (PDT) has extraordinary promise for the treatment of many cancers. However, its clinical progress is impaired by the intrinsic hypoxic tumor microenvironment that limits PDT efficacy and the safety concern associated with biological specificity of photosensitizers or vehicles. Now it is demonstrated that rationally designed DNA nanosponges can load and delivery photosensitizer effectively, target tumor precisely, and relieve hypoxia‐associated resistance remarkably to enhance the efficacy of PDT. Specifically, the approach exhibits a facile assembly process, provides programmable and versatile nanocarriers, and enables robust in vitro and in vivo anti‐cancer efficacy with excellent biosafety. These findings represent a practical and safe approach by designer DNA nanoassemblies to combat cancer effectively and suggest a powerful strategy for broad biomedical application of PDT. Abstract : Designer DNA nanosponges relieve hypoxia‐associated resistance and enhance photodynamic therapy (PDT). The facile assembly process, robust in vitro and in vivo therapeutic efficacy, and good biosafety demonstrate a practical platform of PDT for biomedical applications. This approach also suggests that DNA nanotechnology has great potential for advanced therapeutics.