A Novel lncRNA HOXC-AS3 Acts as a miR-3922-5p Sponge to Promote Breast Cancer Metastasis. (2nd January 2020)

• Record Type: Journal Article
• Authors: Shi, Sheng-Hong; Jiang, Jing; Zhang, Wei; Sun, Long; Li, Xu-Jun; Li, Chao; Ge, Qi-Dong; Zhuang, Zhi-Gang
• Is Part Of: Cancer investigation. Volume 38:Number 1(2020)
• Page Start: 1
• Page End: 12
• Publication Date: 2020-01-02
• Subjects: HOXC-AS3 -- breast cancer -- metastasis -- miR-3922-5p -- PPP1R1A; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2019.1695816
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: Purpose: The function of long noncoding RNAs (lncRNA) in breast cancer metastasis remains largely unknown. In this work, the role of HOXC-AS3 in breast cancer progression was investigated. Methods: By using Cancer Genome Atlas (TCGA) Database, we investigated the expression of HOXC-AS3 in breast cancer and explored the association between HOXC-AS3 expression and prognosis. Then, we studied the biological function of HOXC-AS3 in cell migration and invasion both in vitro and in vivo . Furthermore, the target miRNA of HOXC-AS3, and the target mRNA of miR-3922-5p were proved. Results: HOXC-AS3 is aberrantly overexpressed in breast cancers especially the HER2 + type. Moreover, high expression of HOXC-AS3 has a relationship with poor clinical outcomes of breast cancer. In addition, HOXC-AS3 regulates cell Invasion and migration both in vitro and in vivo . Our results demonstrated that miR-3922-5p was a direct target of HOXC-AS3, and PPP1R1A was a target of miR-3922-5p in breast cancer. Conclusions: The novel lncRNA HOXC-AS3 acts as a miR-3922-5p sponge to upregulate PPP1R1A protein expression, and thus results in promoting breast cancer metastasis. HOXC-AS3 could be a novel therapeutic target for breast cancer therapeutics.