Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG)-Positive Optic Perineuritis. (2nd January 2020)

• Record Type: Journal Article
• Authors: Lopez-Chiriboga, A. Sebastian; Van Stavern, Gregory; Flanagan, Eoin P.; Pittock, Sean J.; Fryer, Jim; Bhatti, M. Tariq; Chen, John J.
• Is Part Of: Neuro-ophthalmology. Volume 44:Number 1(2020)
• Page Start: 1
• Page End: 4
• Publication Date: 2020-01-02
• Subjects: Optic perineuritis -- myelin oligodendrocyte glycoprotein (MOG) -- aquaporin-4 (AQP4) -- optic neuritis -- optic nerve sheath; Neuroophthalmology -- Periodicals; 617.7
• DOI: 10.1080/01658107.2019.1607883
• Languages: English
• ISSNs: 0165-8107

Abstract

ABSTRACT: Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but the majority of cases are idiopathic. Myelin oligodendrocyte glycoprotein (MOG)-IgG-positive optic neuritis has been reported to be associated with optic nerve sheath enhancement. This report describes two MOG-IgG patients with clinical, radiological and therapeutic response consistent with optic perineuritis. MOG-IgG may account for many cases of previously described idiopathic optic perineuritis. Vision loss with optic nerve sheath enhancement on MRI should prompt testing for MOG-IgG.