Diallyl sulfide alleviates cyclophosphamide-induced nephropathic encephalopathy in rats. (23rd March 2020)

• Record Type: Journal Article
• Authors: Galal, Shereen M.; Mansour, Heba H.; Elkhoely, Abeer A.
• Is Part Of: Toxicology mechanisms and methods. Volume 30:Number 3(2020)
• Page Start: 208
• Page End: 218
• Publication Date: 2020-03-23
• Subjects: Diallyl sulfide -- cyclophosphamide -- glial fibrillary acidic protein -- N-methyl-D-aspartate/adenosine triphosphate -- γ-aminobutyric acid -- nitric oxide; Analytical toxicology -- Periodicals; Toxicology -- Periodicals; Toxicology -- Methodology -- Periodicals; 615.907
• DOI: 10.1080/15376516.2019.1695991
• Languages: English
• ISSNs: 1537-6516

Abstract

Abstract: Diallyl sulfide (DAS) is a garlic-derived organosulfur compound. The current study was planned to evaluate the protecting effects of DAS against cyclophosphamide (CP)-induced nephropathic encephalopathy. DAS (100 mg/kg) was orally administered for 4 days, 60 min after the last dose, rats were injected with CP (150 mg/kg). DAS treatment before CP significantly decreased serum urea, creatinine, sodium, potassium, calcium, blood urea nitrogen (BUN), C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1β (IL-1ß) and tumor necrosis factor-alpha (TNF-α) compared with CP-treated rats. DAS treatment decreased malondialdehyde (MDA) and increased superoxide dismutase (SOD) and reduced glutathione (GSH) levels in the renal tissues and significantly attenuated the elevated neurotransmitters N-methyl-D-aspartate/adenosine triphosphate (NMDA), γ-aminobutyric acid (GABA) levels and remarkably restored neuronal nitric oxide (NO) level and nitric oxide synthase (nNOS) activity in the brain compared to CP-treated rats. DAS for 4 consecutive days before CP showed moderate positive immunohistochemically expression of the glial fibrillary acidic protein (GFAP) in the brain and kidney tissues comparable to CP-treated rats. DAS afforded renal and neuroprotection against CP-induced nephropathic encephalopathy due to its capacity to ameliorates the afore-mentioned biochemical parameters which were supported by histopathological and immunohistochemically examination.