Efficient solvent- and temperature-tuned access to aldoxime ethers and phenolic functions by Pd-catalyzed C–O cross-coupling of aldoximes with aryl bromides and bromo-chalcones. (6th January 2020)

• Record Type: Journal Article
• Authors: Reeta, ; Rangarajan, T. M.; Kaushik, Kumar; Singh, Rishi Pal; Singh, Manjula; Singh, Raj Pal
• Is Part Of: New journal of chemistry. Volume 44:Number 4(2020)
• Page Start: 1326
• Page End: 1336
• Publication Date: 2020-01-06
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c9nj05124d
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A single method with a functionality switching option, to access oxime ethers and phenols, was developed for the first time for the Pd-catalyzed C–O cross-coupling of aryl bromides and bromo-chalcones with aldoximes. Abstract : A single method with a functionality switching option was developed for the first time for the Pd-catalyzed C–O cross-coupling of aryl bromides and bromo-chalcones with aldoximes. The ligand t BuXPhos (L2 ) was found to be an effective supporting ligand for the Pd-catalyzed coupling of aldoximes with bromo coupling partners. The functionality switching from oxime ethers to a phenolic or hydroxy group was driven by solvent or temperature. This method offers the products in good to excellent yields in short reaction times.