A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium. (February 2020)

• Record Type: Journal Article
• Authors: Jensen, Andreas I.; Zhuravlev, Fedor; Severin, Gregory; Magnus, Charlotte Busk; Fonslet, Jesper; Köster, Ulli; Jensen, Mikael
• Is Part Of: Applied radiation and isotopes. Volume 156(2020:Feb.)
• Publication Date: 2020-02
• Subjects: Auger radiotherapy -- Radionuclide generator -- Rhodium-103m -- Palladium-103 -- 16aneS4; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2019.108985
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m ( 103m Rh, T½ = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 ( 103 Pd, T½ = 16.99 days). 103 Pd was chelated in a lipophilic derivative of the 16aneS4 macrocycle and the complex was trapped on a C18 cartridge. Elution with dilute hydrochloric acid gave radiochemically pure 103m Rh. We hypothesize this to be through a combination of the Szilard-Chalmers effect and transient ionization. Highlights: [ 103 Pd]PdCl2 was obtained by dissolving neutron irradiated 102 Pd-enriched targets. [ 103 Pd]Pd was chelated by a 16aneS4-octyl derivative and trapped on a C18 support. Elution of this generator provided 103m Rh in excellent radiochemical purity. The demonstrated generator will allow investigating 103m Rh for Auger radiotherapy.