Phonophoresis of Phyllanthus amarus nanoparticle gel improves functional capacity in individuals with knee osteoarthritis: A randomized controlled trial. Issue 1 (January 2020)

• Record Type: Journal Article
• Authors: Pinkaew, Decha; Kiattisin, Kanokwan; Wonglangka, Khanittha; Awoot, Pisittawoot
• Is Part Of: Journal of bodywork and movement therapies. Volume 24:Issue 1(2020:Jan.)
• Page Start: 15
• Page End: 18
• Publication Date: 2020-01
• Subjects: Knee osteoarthritis -- Phyllanthus amarus -- Phonophoresis -- Ultrasound therapy -- 6-minute walk test; Massage -- Periodicals; Exercise therapy -- Periodicals; Manipulation (Therapeutics) -- Periodicals; Electronic journals; 615.82
• DOI: 10.1016/j.jbmt.2019.04.013
• Languages: English
• ISSNs: 1360-8592

Abstract

Abstract: Objective: This study examined the effects of treatment with Phyllanthus amarus nanoparticle gel applied by phonophoresis (PP) and ultrasound therapy (UT) in patients with symptomatic knee osteoarthritis (OA) using a randomized, double-blind, controlled trial. Methods: Patients with knee OA (n = 40; mean age ± SD, 64.30 ± 9.71 years), who had visual analogue scale (VAS) scores for knee pain intensity of 68.00 ± 9.58 (UT group) and 71.00 ± 8.74 (PP group, respectively) before treatment, were randomly allocated into two groups. Both groups were treated with an ultrasound program in continuous mode, 1.0 W/cm 2, 10 min per session, for 10 sessions. Nanoparticles of P. amarus were used in the PP group, whereas a nondrug coupling gel was used in the UT group. The 6-min walk test (6-MWT) was performed to evaluate functional capacity. The VAS and the 6-MWT were evaluated before and after 10 treatment sessions in both groups using a double-blind procedure. Results: VAS and 6-MWT showed significant improvement after treatment in both groups (p < 0.05). The PP group showed more significant effects than the UT group, in terms of both reducing the VAS pain score (p < 0.05) and improving 6-MWT (p < 0.05). Conclusions: PP is suggested as an effective method for the treatment of symptomatic knee OA for reducing pain and improving functional capacity.