Synthesis of γ-lactams via trifluoromethylative aminocarbonylation of unactivated olefins. Issue 7 (13th February 2020)

• Record Type: Journal Article
• Authors: Liu, Jige; Chen, Dong; Ji, Meishan; Wu, Xinxin; Zhu, Chen
• Is Part Of: Tetrahedron letters. Volume 61:Issue 7(2020)
• Publication Date: 2020-02-13
• Subjects: Lactam -- Radical reaction -- Alkene difunctionalization -- Trifluoromethyl; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.151479
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Novel approach for radical-mediated trifluoromethylative aminocarbonylation of unactivated olefins. The reaction features mild conditions, good functional group tolerance, and broad substrate scope. The CF3 -functionalized γ-lactam products are synthetically valuable. Abstract: An efficient approach for the synthesis of γ-lactams through radical-mediated trifluoromethylative aminocarbonylation of unactivated olefins is described. The transformation is initiated by the addition of an external CF3 radical to alkene followed by interception with intramolecular cyanamide. This protocol provides a useful method to furnish the synthetically valuable CF3 -functionalized γ-lactams.