High incidence of severe neurological manifestations and high mortality rate for adult Listeria monocytogenes meningitis in Taiwan. (January 2020)

• Record Type: Journal Article
• Authors: Chen, Shih-Ying; Lee, Jun-Jun; Chien, Chun-Chih; Tsai, Wan-Chen; Lu, Cheng-Hsien; Chang, Wen-Neng; Lien, Chia-Yi
• Is Part Of: Journal of clinical neuroscience. Volume 71(2020)
• Page Start: 177
• Page End: 185
• Publication Date: 2020-01
• Subjects: L. monocytogenes meningitis -- Adults -- Altered consciousness -- Seizure -- Bacteremia -- Hydrocephalus; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2019.08.072
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Listeria (L.) monocytogenes meningitis in adults is rarely examined solely in the literature. 11 adult L. monocytogenes meningitis were identified between 2000 and 2018. Clinical features of the 11 adults with L. monocytogenes meningitis were analyzed. Analysis of the clinical features of 8 other reported cases of L. monocytogenes meningitis. High incidence of altered consciousness, seizure, bacteremia, and hydrocephalus were found. High mortality (8/11, 72.7%) was found in adults with L. monocytogenes meningitis. Abstract: The clinical characteristics and therapeutic outcomes of adult Listeria monocytogenes meningitis are not commonly examined in isolation in the literature. During a study period of 19 years (2000–2018), 366 patients with culture-proven adult bacterial meningitis (ABM) were identified in the author's hospital (264 patients in 2000–2010 and 102 patients in 2011–2018). Of the 366 ABM patients, 330 had monomicrobial infections while the other 36 had mixed infections. L. monocytogenes infection was identified in 11 of the 330 patients with monomicrobial ABM (3 in 2000–2010 and 8 in 2011–2018). These 11 patients included 5 males and 6 females, aged 47 to 76 years (median age = 61.7). None of the 11 patients had a postneurosurgical state as the underlying cause, but 3 of them contracted the infection nosocomially. Common underlying conditions included liver cirrhosis (4), systemic malignancy (3), diabetes mellitus (3), and renal disease (2). The most common clinical manifestations were fever (11), altered consciousness (8), seizure (8), bacteremia (7) and hydrocephalus (5). The therapeutic result revealed a mortality rate of 72.7% (8/11), but no significant prognostic factors were identified. The clinical features of 8 additional Taiwanese L. monocytogenes ABM patients reported in the literature, were also included for analysis. The present study revealed an increase in L. monocytogenes ABM in recent years and most patients presented with severe neurological manifestations. The current study is a preliminary overview of L. monocytogenes meningitis in adults and a further large-scale study is needed for improved delineation of this specific infectious syndrome.