The effects of high doses of vitamin D on the composition of the gut microbiome of adolescent girls. (February 2020)

• Record Type: Journal Article
• Authors: Tabatabaeizadeh, Seyed-Amir; Fazeli, Mostafa; Meshkat, Zahra; Khodashenas, Ezzat; Esmaeili, Habibollah; Mazloum, Seyedreza; Ferns, Gordon A.; Abdizadeh, Mojtaba Fattahi; Ghayour-Mobarhan, Majid
• Is Part Of: Clinical nutrition ESPEN. Volume 35(2020)
• Page Start: 103
• Page End: 108
• Publication Date: 2020-02
• Subjects: Vitamin D -- Microbiome -- Adolescents -- Inflammatory bowel disease; Nutritionally induced diseases -- Periodicals; Metabolism -- Disorders -- Periodicals; 616.39005
• DOI: 10.1016/j.clnesp.2019.10.020
• Languages: English
• ISSNs: 2405-4577

Abstract

Summary: Background: Animal studies suggest that vitamin D can change the gut microbiome. The primary aim of this study was to evaluate the effect of a high dose supplementation of vitamin D on the composition of the gut microbiome. Methods: After DNA extraction, TaqMan assays were used for the quantitation of selected microbiome in the feces of 50 adolescent girls before and after vitamin D supplementation. Results: The expression fold changes for Enterococcus, Bifidobacterium, Lactobacillus, Bacteroidetes and Firmicutes were; 1.05, 1.20, 0.76, 0.28 and 1.50 respectively. Bacteroidetes and Lactobacillus fell by 72% (P < 0.0001) and 24% (P = 0.006) respectively, whilst Firmicutes and Bifidobacterium were increased by 1.5 (P < 0.0001), 1.2 (P < 0.0001) fold after supplementation. Conclusion: Our results suggested that a high dose supplementation of vitamin D alter the human gut microbiome composition. Future studies are required for a better understanding of the mechanisms by which vitamin D affects the gut microbiome.