Latest advances in zwitterionic structures modified dialysis membranes. (March 2020)

• Record Type: Journal Article
• Authors: Mollahosseini, A.; Abdelrasoul, A.; Shoker, A.
• Is Part Of: Materials today chemistry. Volume 15(2020)
• Publication Date: 2020-03
• Subjects: Hemodialysis -- Blood -- Hemocompatibility -- Zwitterionization -- Interactions -- Activations -- Surface modification; Zwitterionic material ZW -- Sulfobetaine methacrylate SBMA -- Water contact angle WCA -- Polystyrene pr -- Polyvinlypyrolidone PVP -- Glycidyl methacrylate GMA -- Polydimethylsiloxane PDMS -- enzyme-linked immunosorbent assay ELISA -- Ethylenediamine EDA -- Sodium polystyrene sulfonate SSNa -- Ammonium persulfate APS -- 2-Hydroxyethyl methacrylate HEMA -- (3-carboxypropylbetaine-propyl)-trimethoxysilane CPPT -- (3-sulfopropylbetaine-propyl)-trimethoxysilane SPPT -- (3-sulfobutylbetaine-propyl)-trimethoxysilane SBMT -- N, N-Dimethyl-N-(p-vinylbenzyl)-N-(3-sulfopropyl)ammonium DMSVA -- rat bone marrow-derived stromal cells rMSCs -- platelet-poor plasma PPP -- N, N-dimethyl-N-methacryloxyethyl-N-(3-sulfopropyl) ammonium DMMSA -- Ceric ammonium nitrate CAN -- 2-dimethylaminopryridine DAMP -- tetrahydrofuran THF -- Triethylamine TEA -- N, N dimethyl- N-(p-vinylbenzyl)-N-(3-sulfopropyl) ammonium PDMVSA -- random radical polymerization RRP -- human serum albumin HSA -- Scanning electron microscopy SEM -- (MPC)-co-n-butyl methacrylate) BMA -- 2-methacryloyloxyethyl phosphorylcholine MPC -- butyl methacrylate BMA -- N, N-diethyl-N-propargyl-N-(3-sulfopropyl) ammonium DEPAS -- sodium methacrylate MAANa -- N, N' -Methylenebisacrylamide MBA -- tri-layer polyelectrolyte TLP -- poly(acrylic acid)-g-azide PAA-g-AZ -- Acrylic acid AA -- Poly (lactic acid) PLA -- N, N′-methylene bisacrylamide MBAA -- Hexamethylenediisocyanate HDI -- 4-vinylpyrrolydene-r-octadecyl acrylate zP(4VP-r-ODA) -- [3-(methacryloylamino)propyl]- dimethyl(3-sulfopropyl) ammonium hydroxide MPDSAH -- [3-(methacryloylamino)propyl]dimethyl(3-sulfopropyl)ammonium hydroxide inner salt SBAA -- cellulose triacetate CTA -- Poly (methyl methacrylate) PMMA -- ethylene vinyl alcohol EVAL -- hazard ratio HR -- activated partial thromboplastin time APTT -- Thrombin time TT -- Prothrombin time PT -- Thrombin-antithrombin III complex TAT -- Platelet factor 4 PF4 -- Polymorphonuclear elastase PMN -- Tissue factor TF -- Adenosine diphosphate ADP -- β-thromboglobulin β-TG -- Glycoprotein IIb/IIIa GP IIb/IIIa -- Membrane attack complex MAC -- Thromboxane A2 TXA2 -- Von Willebrand factor vWF -- Flux recovery ratio FRR -- Total resistance Rt -- Irreversible resistance Rir -- Reversible resistance Rr -- Water contact angle WCA -- partial thromboplastin time APTT -- Thrombin time TT -- Prothrombin time PT -- thrombin-antithrombin III TAT -- platelet factor 4 PF4 -- phosphate buffer saline solution PBS; Chemistry -- Periodicals; Materials -- Research -- Periodicals; Materials science -- Periodicals; Chemistry; Materials -- Research; Electronic journals; Periodicals; 660.282
• DOI: 10.1016/j.mtchem.2019.100227
• Languages: English
• ISSNs: 2468-5194

Abstract

Abstract: End-stage renal diseases are affecting many patients and as a result, demand to receive dialysis service is growing annually. Morbidity and mortality rates are reported to be higher in comparison with healthy humans. The reason is reported to be the hemoincompatiblity of blood purification membranes, which hinders patients' lives. Activation of different immune systems in the body, in case of blood-membrane interaction, results in several side effects, of which cardiovascular shocks have been mentioned to be a major one. Efforts to solve this issue have resulted in different generations of dialysis membranes. Zwitterionic immobilized membranes are the latest (third) generation, which owns a higher degree of hemocompatiblity with more stability of immobilized structures. This critical review intends to cover recent efforts conducted over the zwitterionization of polymeric membrane surfaces with the goal of improving hemocompatibility. Different aspects of third-generation membranes are discussed for a better understanding of the current gap and gathering the knowledge to further develop the field. Accordingly, this critical survey provides an in-depth understanding of blood purification membranes zwitterionization for paving the way for the optimum enhancement of hemodialysis membrane hemocompatibility. Graphical abstract: Polymeric hollow fibers cross-section for hemodialysis; (a) with the modified surface structure using zwitterionic materials resulting in low blood cascade activation and minimized clotting, (b) untreated inner surface with blood protein attachment, cascade activation, and clotting. Image 1 Highlights: Three generations of hemodialysis membranes were reviewed. Influence of zwitterionic-immobilized polymeric membranes on hemocomptability. Immobilization techniques of zwitterionization and its influences on hemocomptability. Critical assessments of hemocomptability of various zwitterionic membranes. Key findings of fibrinogen and proteins adsorption.