Anxiolytic and antidepressant-like effects of Annona coriacea (Mart.) and caffeic acid in mice. (February 2020)

• Record Type: Journal Article
• Authors: Monteiro, Álefe Brito; Kelly de Souza Rodrigues, Cristina; Petícia do Nascimento, Emmily; Sales, Valterlúcio dos Santos; de Araújo Delmondes, Gyllyandeson; Nogueira da Costa, Maria Haiele; Pereira de Oliveira, Victor Afonso; Pereira de Morais, Luis; Boligon, Aline Augusti; Barbosa, Roseli; Martins da Costa, José Galberto; Alencar de Menezes, Irwin Rose; Bezerra Felipe, Cícero Francisco; Kerntopf, Marta Regina
• Is Part Of: Food and chemical toxicology. Volume 136(2020)
• Publication Date: 2020-02
• Subjects: Annona coriacea -- Caffeic acid -- Anxiolytic-like effect -- GABAergic system -- Antidepressant-like effect -- Monoaminergic system; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2019.111049
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: This research evaluated the anxiolytic and antidepressant-like effects of a hydroethanolic extract from the leaves of Annona coriacea (EHFAC) and caffeic acid (CA). Mice were intraperitoneally treated with saline, EHFAC (1, 10, 20 mg/kg) or CA (0.15 mg/kg) and subject to the elevated plus-maze, open field, rota-rod, forced swimming and reserpine-induced akinesia tests. Pro-convulsant and anticholinergic effects were also evaluated. EHFAC presented anxiolytic-like effect on the elevated plus-maze, which was partially reversed by flumazenil. A similar effect was observed with CA. In the forced swimming test, EHFAC and CA reduced the immobility time of mice; such effect was potentiated when EHFAC or CA were associated with imipramine, bupropion and fluoxetine. The antidepressant-like effect was reinforced as EHFAC partially reversed the reserpine-induced akinesia. In addition, a pre-treatment with EHFAC and CA did not decrease the latency to 1st seizure of animals that received a sub-convulsive dose of PTZ, nor reduced the intensity of oxotremorine-induced tremors. Taken together, the results indicate that EHFAC and CA have anxiolytic and antidepressant-like effects, which involve important neurotransmitter systems, such as GABAergic and monoaminergic ones, being devoid of side effects, commonly associated with classical psychotropic drugs. Highlights: Anxiolytic and antidepressant-like effects are reported. Possible involvement of the GABAergic and monoaminergic systems. Devoid of side effects commonly associated with classical psychotropic drugs.