Enantioanalysis of tryptophan in whole blood samples using stochastic sensors—A screening test for gastric cancer. Issue 2 (20th November 2019)

• Record Type: Journal Article
• Authors: Ilie‐Mihai, Ruxandra‐Maria; Stefan‐van Staden, Raluca‐Ioana; Magerusan, Lidia; Coros, Maria; Pruneanu, Stela
• Is Part Of: Chirality. Volume 32:Issue 2(2020)
• Page Start: 215
• Page End: 222
• Publication Date: 2019-11-20
• Subjects: d‐tryptophan -- gastric cancer -- graphene -- l‐tryptophan -- stochastic sensors -- whole blood samples; Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.23155
• Languages: English
• ISSNs: 0899-0042

Abstract

Abstract: Tryptophan is a key amino acid related to metabolomics in gastric cancer. To date, methods were developed only for the assay of l ‐tryptophan, the role of d ‐tryptophan being not yet established. Therefore, four stochastic sensors based on different graphene materials modified with β‐cyclodextrins, 2, 2‐diphenyl‐1‐picrylhydrazyl, and protoporphyrin IX were designed and used for enantioanalysis of tryptophan in whole blood samples. High sensitivities, and reliabilities were recorded when the stochastic sensors were used for the enantioanalysis of tryptophan in whole blood samples. The paper opened a new chapter in early detection of gastric cancer, based on establishing the role of d ‐tryptophan in metabolomics, and in early diagnosis of gastric cancer. Abstract :