Graphene Hybrid Anisotropic Structural Color Film for Cardiomyocytes' Monitoring. (22nd October 2019) - Li, Linjie
Abstract: Heart‐on‐a‐chip based on microfluidic platform can simulate the structure and reveal the function of heart at the micrometer level, compensating the gap between organism and experiments in vitro. In this paper, a novel heart‐on‐a‐chip system integrated with reduced graphene oxide (rGO) hybrid anisotropic structural color film is designed for cardiac sensing and evaluation. This hybrid anisotropic film is based on the opposite adhesion properties of the polyethylene glycol diacrylate (PEGDA) and gelatin methacryloyl (GelMA). The PEGDA area with low adhesion rate has inverse opal structure and specific reflection peak, while microgroove‐patterned rGO‐doped GelMA area with high adhesion rate provides the cardiomyocytes with excellent growing environment and induced orientation property. Benefiting from the design, the cultured cardiomyocytes only adhere in specific area without affecting the surface microstructure of the structural color. When cardiomyocytes recover beating, its elongation and contraction will stretch the structure of PEGDA and result in a color shift, which realizes the transformation from micromechanics to macroscopic optics. In addition, the heart‐on‐a‐chip system based on the anisotropic structural color hydrogels and microfluidics provides an outstanding visible method for cardiac sensing, which is of great significance in cardiac pathophysiological studies and drug detection in vitro. Abstract : A novel heart‐on‐a‐chip system integrated with a reduced graphene oxide hybrid anisotropic structural color film is designed for cardiac sensing and evaluation. This new type of structural color film separates the microgroove‐patterned cell culture area inducing cardiomyocytes' orientation growth from the inverse opal visible sensing area. Beating cardiomyocytes cause lattice changes in the inverse opal and shifts the structural colors.