NIR/ROS‐Responsive Black Phosphorus QD Vesicles as Immunoadjuvant Carrier for Specific Cancer Photodynamic Immunotherapy. (28th October 2019)

• Record Type: Journal Article
• Authors: Li, Zhi; Hu, Yuehua; Fu, Qinrui; Liu, Yang; Wang, Jie; Song, Jibin; Yang, Huanghao
• Is Part Of: Advanced functional materials. Volume 30:Number 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-10-28
• Subjects: black phosphorus quantum dots -- immunotherapy -- photoacoustic imaging -- photodynamic therapy -- self‐assembly; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201905758
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: 2D black phosphorus (BP) nanosheets and BP quantum dots (BPQD), as two main material styles of BP, are widely used in the biomedical filed. However, few stimuli‐responsive BP nanocarriers are reported to meet the need of nanomedicine. Herein, near‐infrared region/reactive oxygen species (NIR/ROS) sensitive BPQD vesicles (BPNVs) are prepared by self‐assembly of amphiphilic BPQDs grafted with polyethylene glycol and ROS sensitive poly(propylene sulfide) (PPS). BPNVs exhibit enhanced photo‐absorption in the NIR region, and have high loading efficiency of immunoadjuvant CpG oligodeoxynucleotides (CpG ODNs) in the cavity of the BPNVs. Upon NIR laser irradiation, high levels of ROS are generated from BPNVs to trigger the change of hydrophobic PPS to hydrophilic polymers, leading to disassembly of the vesicles to BPQDs. In this manner, the BPNVs show synergistic photodynamic therapy combined with immunotherapy, due to simultaneous release of small BPQDs with deep tumor penetration and CpG with enhanced immunotherapy. The BPNVs‐CpG achieves potent photodynamic immunotherapy in vivo, in addition to block distant tumor growth and metastasis. Abstract : Black phosphorus quantum dots‐based nanovesicles (BPNVs) with enhanced optical properties and near‐infrared region/reactive oxygen species (NIR/ROS)‐responsiveness are developed and encapsulated with CpG oligodeoxynucleotides for forming BPNVs‐CpG. The BPNVs‐CpG not only enables deep tumor penetration by controllable dissociation of the BPNVs upon NIR irradiation, but also induces a potent anti‐cancer photodynamic immunotherapeutic.