Bone Replacement: The Secretome of Hypoxia Conditioned hMSC Loaded in a Central Depot Induces Chemotaxis and Angiogenesis in a Biomimetic Mineralized Collagen Bone Replacement Material (Adv. Healthcare Mater. 2/2020). Issue 2 (22nd January 2020)

• Record Type: Journal Article
• Authors: Quade, Mandy; Münch, Pina; Lode, Anja; Duin, Sarah; Vater, Corina; Gabrielyan, Anastasia; Rösen‐Wolff, Angela; Gelinsky, Michael
• Is Part Of: Advanced healthcare materials. Volume 9:Issue 2(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-22
• Subjects: homing -- hypoxia conditioned stem cell secretome -- in situ tissue engineering -- mineralized collagen -- vascularization; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202070005
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : In article number 1901426 by Anja Lode and co‐workers, sustained release of hypoxia‐conditioned MSC secretome from a central depot induces directed hBMSC migration and angiogenesis in biomimetic mineralized collagen scaffolds. This in situ tissue engineering concept is suggested to be a cell‐free and ready‐to‐use therapeutic solution for accelerated bone defect healing.