Physiologic Model for Seasonal Patterns in Flu Transmission. (13th March 2019)

• Record Type: Journal Article
• Authors: Ference, Ryan S.; Leonard, James A.; Stupak, Howard D.
• Is Part Of: Laryngoscope. Volume 130:Number 2(2020)
• Page Start: 309
• Page End: 313
• Publication Date: 2019-03-13
• Subjects: Flu -- vapor pressure -- relative humidity -- absolute humidity -- mucociliary dysfunction; Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.27910
• Languages: English
• ISSNs: 0023-852X

Abstract

Abstract : Seasonal patterns in flu transmission have observational validity in temperate climates. However, there is no consensus mechanism explaining the increased incidence of flu during the winter. The physiologic effects of cold weather and dry air on the upper respiratory system may contribute to immune dysfunction and increased susceptibly to flu‐causing pathogens. Low temperature limits the absolute humidity of air. Persistent exposure to dry air leads to airway desiccation and failure of the mucociliary system. The resultant physiologic and histopathologic changes that occur in the airway increase susceptibility to flu‐causing pathogens. Laryngoscope, 130:309–313, 2020