The effectiveness of Botulinum Toxin A for treatment of upper limb impairments and dysfunctions in breast cancer survivors: A randomised controlled trial. (30th September 2019)

• Record Type: Journal Article
• Authors: De Groef, An; Devoogdt, Nele; Van Kampen, Marijke; De Hertogh, Laura; Vergote, Margot; Geraerts, Inge; Dams, Lore; Van der Gucht, Elien; Debeer, Philippe
• Is Part Of: European journal of cancer care. Volume 29:Number 1(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-09-30
• Subjects: botulinum toxins -- breast neoplasms -- pectoralis muscles -- physical therapy modalities -- shoulder function; Cancer -- Nursing -- Periodicals; 616.994
• DOI: 10.1111/ecc.13175
• Languages: English
• ISSNs: 0961-5423

Abstract

Abstract: Objective: To examine the effectiveness of a single Botulinum Toxin A (BTX‐A) infiltration in the pectoralis major muscle, in addition to a standard physical therapy (PT) programme on upper limb impairments and dysfunctions after breast cancer treatment. Methods: Fifty breast cancer patients with persistent pain 3 months after finishing treatment participated in a double‐blinded randomised controlled trial. The intervention group received a single BTX‐A infiltration. The control group received a placebo (saline) infiltration. Within one week after the infiltration, all patients attended an individual PT programme (12 sessions) during the first 3 months. Outcome parameters were active shoulder range of motion, upper limb strength, scapular statics and shoulder function. Measures were taken before the intervention, at 1, 3 (i.e. after the intervention) and 6 months follow‐up. Results: No differences between groups were found for all outcome parameters over the course of 6 months. However, overall beneficial effects of the PT for active forward flexion shoulder range of motion and shoulder function were found in both groups. Conclusion: A single Botulinum Toxin A (BTX‐A) infiltration in the pectoralis major muscle, in addition to a PT programme cannot be recommended to treat upper limb impairments and dysfunctions after breast cancer treatment.