Efficient Enantioselective Syntheses of Chiral Natural Products Facilitated by Ligand Design. Issue 1 (26th April 2019)

• Record Type: Journal Article
• Authors: Yang, He; Tang, Wenjun
• Is Part Of: Chemical record. Volume 20:Issue 1(2020)
• Page Start: 23
• Page End: 40
• Publication Date: 2019-04-26
• Subjects: asymmetric synthesis -- total synthesis -- cross coupling -- cyclization -- chiral ligands; Chemistry -- Periodicals; 540
• DOI: 10.1002/tcr.201900003
• Languages: English
• ISSNs: 1527-8999

Abstract

Abstract: The employment of enantioselective transition‐metal‐catalyzed transformations as key steps in asymmetric natural product syntheses have attracted considerable attention in recent years owing to their versatile synthetic utilities, mild conditions and high efficiency in chirality generation. The chiral catalysts or supporting ligands are believed to be crucial for the requisite reactivity and enantioselectivity. Therefore, the rational design of chiral ligands is at the heart of developing new asymmetric transition‐metal catalyzed reactions and provides an avenue to the asymmetric synthesis of natural products. Our group has been engaged in the development of transition‐metal‐catalyzed enantioselective cross‐coupling, cyclization and other related reactions and the application of these methodologies to natural product syntheses. In this account, we summarized our recent synthetic efforts towards the efficient total syntheses of several different types of natural products including terpenes, alkaloids and polyketides facilitated by the design of a series of versatile P‐chiral phosphorous ligands. Abstract : The rational design of chiral ligands is at the heart of developing new asymmetric transition‐metal catalyzed reactions which have significantly facilitated natural product syntheses. This account showcases the superior performance of a class of P‐chiral phosphorus ligands in asymmetric cross‐coupling, cyclization, and α‐arylation reactions that have been applied as key steps in natural product syntheses.