2D MXene‐Integrated 3D‐Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction. Issue 2 (26th November 2019)

• Record Type: Journal Article
• Authors: Pan, Shanshan; Yin, Junhui; Yu, Luodan; Zhang, Changqing; Zhu, Yufang; Gao, Youshui; Chen, Yu
• Is Part Of: Advanced science. Volume 7:Issue 2(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-11-26
• Subjects: bone tumors -- MXenes -- photothermal therapy -- scaffolds -- tissue engineering; Science -- Periodicals; 505
• DOI: 10.1002/advs.201901511
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: The residual of malignant tumor cells and lack of bone‐tissue integration are the two critical concerns of bone‐tumor recurrence and surgical failure. In this work, the rational integration of 2D Ti3 C2 MXene is reported with 3D‐printing bioactive glass (BG) scaffolds for achieving concurrent bone‐tumor killing by photonic hyperthermia and bone‐tissue regeneration by bioactive scaffolds. The designed composite scaffolds take the unique feature of high photothermal conversion of integrated 2D Ti3 C2 MXene for inducing bone‐tumor ablation by near infrared‐triggered photothermal hyperthermia, which has achieved the complete tumor eradication on in vivo bone‐tumor xenografts. Importantly, the rational integration of 2D Ti3 C2 MXene is demonstrated to efficiently accelerate the in vivo growth of newborn bone tissue of the composite BG scaffolds. The dual functionality of bone‐tumor killing and bone‐tissue regeneration makes these Ti3 C2 MXene‐integrated composite scaffolds highly promising for the treatment of bone tumors, which also substantially broadens the biomedical applications of 2D MXenes in tissue engineering, especially on the treatment of bone tumors. Abstract : The rational design of 2D MXenes in tissue‐engineering biomedical field is reported, taking their unique characteristics of highly efficient near‐infrared‐triggered photothermal‐conversion performance and enhanced bone‐tissue regeneration capability, especially on combating bone tumors.