A Novel Strategy for Quantifying Clopidogrel Using Square‐wave Voltammetry and a Boron‐doped Diamond Film. Issue 1 (10th September 2019)

• Record Type: Journal Article
• Authors: Nascimento, Louise Oliveira; Scremin, Jessica; Mattos, Gabriel Junquetti; Gomes, Adriana; Clausen, Débora Nobile; Sartori, Elen Romão
• Is Part Of: Electroanalysis. Volume 32:Issue 1(2020)
• Page Start: 191
• Page End: 197
• Publication Date: 2019-09-10
• Subjects: antiplatelet agent -- boron-doped diamond electrode -- electrochemical sensor -- pharmaceutical formulations -- square-wave voltammetry; Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.201900219
• Languages: English
• ISSNs: 1040-0397

Abstract

Abstract: The voltammetric behavior of clopidogrel bisulfate (CLO), an antiplatelet agent, was investigated for the first time in the literature on a cathodically pretreated boron‐doped diamond electrode (CP‐BDDE) using cyclic (CV) and square‐wave voltammetry (SWV). It was observed an anodic peak for CLO, suitable for analytical purposes, at about 1.15 V (vs. Ag/AgCl (3.0 mol L −1 KCl)) by CV in Britton‐Robinson buffer solution (pH 5.0). On the physical‐chemical characterization of the interface phenomena, it was proved that electrode reaction of the analyte was controlled by a diffusion process. At optimized square‐wave parameters (pulse amplitude of 60 mV, frequency of 30 Hz and scan increment of 3 mV), the obtained analytical curve was linear for the CLO concentration range from 0.60 to 60.0 μmol L −1, with a detection limit of 0.60 μmol L −1 . The simple, rapid and greener analytical method, based on CP‐BDDE electrochemical sensor, was successfully applied in real samples (pharmaceuticals and urine). Abstract :