Cascade catalytic nanoplatform for enhanced starvation and sonodynamic therapy. (7th February 2020)

• Record Type: Journal Article
• Authors: Zhang, Yingjie; Wang, Huiling; Jia, Xuedong; Du, Shuzhang; Yin, Yanyan; Zhang, Xiaojian
• Is Part Of: Journal of drug targeting. Volume 28:Number 2(2020)
• Page Start: 195
• Page End: 203
• Publication Date: 2020-02-07
• Subjects: Catalytic reaction -- manganese dioxide nanoparticles -- starvation therapy -- sonodynamic therapy -- magnetic resonance imaging; Drug delivery systems -- Periodicals; Drug Delivery Systems; Vehicles; Drug Administration Routes; Drug Evaluation; 615.7
• DOI: 10.1080/1061186X.2019.1641507
• Languages: English
• ISSNs: 1061-186X

Abstract

Abstract: Background: Sonodynamic therapy (SDT) has emerged as an alternative to the traditional treatments of cancer. However, the oxygen consumption induced by SDT and glucose oxidase (GOx) mediated starvation therapy would worsen the hypoxic tumor environment, which further impeded therapeutic efficacy. Purpose: To develop a nanoplatform and investigate its anti-cancer mechanism for enhanced starvation and SDT. Methods: We constructed a cascade catalytic nanoplatform based on GOx modified the mesoporous MnO2 NPs loaded with hematoporphyrin monomethyl ether (HMME), which were designated as GOx-MnO2 /HMME. We characterized them for their catalytic activity, and investigate the magnetic resonance imaging and anti-tumor efficiency in vitro and in vivo. Results: MnO2 NPs with catalase-like activity could oxidize H2 O2 under acid condition to produce O2, which not only in turn was supplied to the glucose-depletion reaction for an efficient starvation therapy, but also enhanced the 1 O2 generation for HMME mediated SDT effect. In addition, the released Mn 2+ ions in the system were able to enhance the MRI signal. Both in vitro and in vivo experiments suggested the cascade catalytic-therapeutic effect between GOx, MnO2 NPs and HMME, demonstrating the enhanced starvation and SDT.