Cloud hunting: doryphagy, a form of selective autophagy that degrades centriolar satellites. Issue 2 (1st February 2020)
- Record Type:
- Journal Article
- Title:
- Cloud hunting: doryphagy, a form of selective autophagy that degrades centriolar satellites. Issue 2 (1st February 2020)
- Main Title:
- Cloud hunting: doryphagy, a form of selective autophagy that degrades centriolar satellites
- Authors:
- Holdgaard, Søs Grønbæk
Cianfanelli, Valentina
Cecconi, Francesco - Abstract:
- ABSTRACT: The selective clearance of cellular components by macroautophagy (hereafter autophagy) is critical for maintaining cellular homeostasis. In this punctum, we summarize and discuss our recent findings regarding a novel type of selective autophagy that targets centriolar satellites (CS) for degradation, a process we termed doryphagy from the Greek word "doryphoros", standing for "satellite". CS are microtubule-associated protein complexes that regulate centrosome composition. We show that CS degradation is mediated through a direct interaction between GABARAPs and an LC3-interacting region (LIR) motif in the CS protein PCM1. Autophagy-deficient systems accumulate large abnormal CS and consequently display centrosome reorganization and abnormal mitoses. Our findings provide a mechanistic link between autophagy deficiency and centrosome abnormalities and exemplify how mammalian Atg8-family proteins (mATG8s) can regulate substrate specificity.
- Is Part Of:
- Autophagy. Volume 16:Issue 2(2020)
- Journal:
- Autophagy
- Issue:
- Volume 16:Issue 2(2020)
- Issue Display:
- Volume 16, Issue 2 (2020)
- Year:
- 2020
- Volume:
- 16
- Issue:
- 2
- Issue Sort Value:
- 2020-0016-0002-0000
- Page Start:
- 379
- Page End:
- 381
- Publication Date:
- 2020-02-01
- Subjects:
- Centriolar satellites -- centrosome -- doryphagy -- mitosis -- PCM1 -- selective autophagy
Autophagic vacuoles -- Periodicals
Apoptosis -- Periodicals
Cell death -- Periodicals
Lysosomes -- Periodicals
Degeneration (Pathology) -- Periodicals
Autophagy -- Periodicals
Cell Death -- Periodicals
Lysosomes -- Periodicals
Periodicals
571.936 - Journal URLs:
- http://www.tandfonline.com/loi/kaup20#.Vd3NN_lVhBc ↗
http://www.landesbioscience.com/journals/autophagy ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/15548627.2019.1703356 ↗
- Languages:
- English
- ISSNs:
- 1554-8627
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 1835.065800
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 12611.xml