Biodegradable Bi2O2Se Quantum Dots for Photoacoustic Imaging‐Guided Cancer Photothermal Therapy. Issue 1 (5th December 2019)

• Record Type: Journal Article
• Authors: Xie, Hanhan; Liu, Mingqiang; You, Baihao; Luo, Guanghong; Chen, Yue; Liu, Bilu; Jiang, Zhenyou; Chu, Paul K.; Shao, Jundong; Yu, Xue‐Feng
• Is Part Of: Small. Volume 16:Issue 1(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-12-05
• Subjects: 2D layered materials -- Bi2O2Se -- biodegradable -- photoacoustic imaging -- photothermal agents; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201905208
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: As new 2D layered nanomaterials, Bi2 O2 Se nanoplates have unique semiconducting properties that can benefit biomedical applications. Herein, a facile top‐down approach for the synthesis of Bi2 O2 Se quantum dots (QDs) in a solution is described. The Bi2 O2 Se QDs with a size of 3.8 nm and thickness of 1.9 nm exhibit a high photothermal conversion coefficient of 35.7% and good photothermal stability. In vitro and in vivo assessments demonstrate that the Bi2 O2 Se QDs possess excellent photoacoustic (PA) performance and photothermal therapy (PTT) efficiency. After systemic administration, the Bi2 O2 Se QDs accumulate passively in tumors enabling efficient PA imaging of the entire tumors to facilitate imaging‐guided PTT without obvious toxicity. Furthermore, the Bi2 O2 Se QDs which exhibit degradability in aqueous media not only have sufficient stability during in vivo circulation to perform the designed therapeutic functions, but also can be discharged harmlessly from the body afterward. The results reveal the great potential of Bi2 O2 Se QDs as a biodegradable multifunctional agent in medical applications. Abstract : 2D Bi2 O2 Se quantum dots (QDs) are synthesized by a facile top‐down approach. Boasting large photothermal conversion efficiency and excellent photoacoustic performance as well as suitable biodegradability, the Bi2 O2 Se QDs facilitate photoacoustic imaging of the entire tumors in photothermal cancer therapy. The semiconducting QDs are promising as a near‐infrared‐triggered theranostic agent in cancer therapy.