Pharmacokinetics of cefonicid in lactating goats after intravenous, intramuscular and subcutaneous administration, and after a long‐acting formulation for subcutaneous administration. Issue 1 (14th November 2019)

• Record Type: Journal Article
• Authors: Badillo, Elena; Escudero, Elisa; Hernandis, Verónica; Galecio, Juan Sebastián; Marín, Pedro
• Is Part Of: Journal of veterinary pharmacology and therapeutics. Volume 43:Issue 1(2020)
• Page Start: 50
• Page End: 56
• Publication Date: 2019-11-14
• Subjects: cefonicid -- cephalosporins -- goats -- long‐acting formulation -- pharmacokinetics; Veterinary pharmacology -- Periodicals; Therapeutics -- Periodicals; 636.0895105
• DOI: 10.1111/jvp.12825
• Languages: English
• ISSNs: 0140-7783

Abstract

Abstract: The single‐dose disposition kinetics of cefonicid were determined in clinically normal lactating goats ( n = 6) after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration of a conventional formulation, and after subcutaneous administration of a long‐acting formulation (SC‐LA). Cefonicid concentrations were determined by high performance liquid chromatography with ultraviolet detection. The concentration–time data were analysed by noncompartmental pharmacokinetic methods. Steady‐state volume of distribution (Vss ) and clearance (Cl) of cefonicid after IV administration were 0.14 ± 0.03 L/kg and 0.51 ± 0.07 L/h·kg, respectively. Following IM, SC and SC‐LA administration, cefonicid achieved maximum plasma concentrations of 14.46 ± 0.82, 11.98 ± 1.92 and 17.17 ± 2.45 mg/L at 0.26 ± 0.13, 0.42 ± 0.13 and 0.83 ± 0.20 hr, respectively. The absolute bioavailabilities after IM, SC and SC‐LA routes were 75.34 ± 11.28%, 71.03 ± 19.14% and 102.84 ± 15.155%, respectively. After cefonicid analysis from milk samples, no concentrations were found above LOQ at any sampling time. From these data, cefonicid administered at 20 mg/kg each 12 hr after SC‐LA could be effective to treat bacterial infections in lactating animals not affected by mastitis problems.