Assessing predictive accuracy of survival regressions subject to nonindependent censoring. (8th December 2019)

• Record Type: Journal Article
• Authors: Wang, Ming; Long, Qi; Chen, Chixiang; Zhang, Lijun
• Is Part Of: Statistics in medicine. Volume 39:Number 4(2020)
• Page Start: 469
• Page End: 480
• Publication Date: 2019-12-08
• Subjects: informative censoring -- predictive accuracy -- sensitivity analysis -- survival regression; Medical statistics -- Periodicals; Statistique médicale -- Périodiques; Statistiques médicales -- Périodiques; 610.727
• DOI: 10.1002/sim.8420
• Languages: English
• ISSNs: 0277-6715

Abstract

Abstract : Survival regression is commonly applied in biomedical studies or clinical trials, and evaluating their predictive performance plays an essential role for model diagnosis and selection. The presence of censored data, particularly if informative, may pose more challenges for the assessment of predictive accuracy. Existing literature mainly focuses on prediction for survival probabilities with limitation work for survival time. In this work, we focus on accuracy measures of predicted survival times adjusted for a potentially informative censoring mechanism (ie, coarsening at random (CAR); non‐CAR) by adopting the technique of inverse probability of censoring weighting. Our proposed predictive metric can be adaptive to various survival regression frameworks including but not limited to accelerated failure time models and proportional hazards models. Moreover, we provide the asymptotic properties of the inverse probability of censoring weighting estimators under CAR. We consider the settings of high‐dimensional data under CAR or non‐CAR for extensions. The performance of the proposed method is evaluated through extensive simulation studies and analysis of real data from the Critical Assessment of Microarray Data Analysis.