Quality evaluation of traditional Chinese medicines based on fingerprinting. Issue 1 (24th July 2019)

• Record Type: Journal Article
• Authors: Liu, Xiaoyan; Jiang, Wenwen; Su, Mei; Sun, Yue; Liu, Hongming; Nie, Lei; Zang, Hengchang
• Other Names: Liu Huwei guestEditor.
• Is Part Of: Journal of separation science. Volume 43:Issue 1(2020)
• Page Start: 6
• Page End: 17
• Publication Date: 2019-07-24
• Subjects: chemometric methods -- fingerprinting -- quality evaluation -- traditional Chinese medicines; Separation (Technology) -- Periodicals; Chromatographic analysis -- Periodicals; 543.089
• DOI: 10.1002/jssc.201900365
• Languages: English
• ISSNs: 1615-9306

Abstract

Abstract: The usage of traditional Chinese medicines has expanded globally, but the data about authentication, efficacy, and safety is far from sufficient to meet the criteria supporting their use worldwide due to complexity in the composition. Fingerprinting describes integral characterization and reflects interactive aspects of complex components; therefore, it can offer the possibility of evaluating quality of traditional Chinese medicines following the overall principle. Chemometric techniques introduce multivariate analytical methods into fingerprinting to obtain more information that is useful, which is consistent with the holistic thought and plays an important role in research on the substantial basis. In this review, we will start with three aspects to expound the quality evaluation of traditional Chinese medicines based on fingerprints. The analytical techniques used in developing fingerprints including chromatographic methods, spectroscopic methods, and capillary electrophoresis are introduced. Strategies for fingerprints analysis usually based on chemometric methods including unsupervised and supervised pattern recognition are described. Applications of fingerprints for multi‐component quantification, quality control, screening of bioactive components, and fingerprint‐efficacy relationship study are also outlined. Finally, we propose challenges and future perspectives of fingerprints in quality evaluation to promote the development of modernization and internationalization of traditional Chinese medicines.