Acute response to rapid iloprost inhalation using the Breelib™ nebulizer in pulmonary arterial hypertension: the Breelib™ acute study. (September 2019)

• Record Type: Journal Article
• Authors: Richter, Manuel J.; Wan, Jun; Ghofrani, Hossein A.; Seeger, Werner; Gall, Henning; Rieth, Andreas; Tello, Khodr
• Is Part Of: Pulmonary circulation. Volume 9:Number 3(2019)
• Publication Date: 2019-09
• Subjects: pulmonary hypertension -- prostanoid -- aerosol drug therapy -- hemodynamics -- right ventricular function; Pulmonary circulation -- Periodicals; Pulmonary circulation; Electronic journals -- Sciences; Periodicals; 616.24005
• DOI: 10.1177/2045894019875342
• Languages: English
• ISSNs: 2045-8932

Abstract

The Breelib™ nebulizer was designed to reduce iloprost inhalation times for patients with pulmonary arterial hypertension (PAH). In 30 patients with PAH, rapid inhalation of iloprost 2.5 µg using Breelib™ caused significant improvements in invasively measured afterload and cardiac index but not echocardiographic right ventricular strain during 30 min post-inhalation.