In silico screening of potential antidiabetic phytochemicals from Phyllanthus emblica against therapeutic targets of type 2 diabetes. (10th February 2020)

• Record Type: Journal Article
• Authors: Sharma, Priyanka; Joshi, Tushar; Joshi, Tanuja; Chandra, Subhash; Tamta, Sushma
• Is Part Of: Journal of ethnopharmacology. Volume 248(2019)
• Publication Date: 2020-02-10
• Subjects: Type 2 diabetes (T2D) -- Phyllanthus emblica -- Docking -- Drug -- Phytochemicals -- Inhibitors -- Therapeutic targets; T2D Type 2 Diabetes -- GLP-1 agonists Glucagon-like peptide receptor agonists -- SGLT2 Sodium-glucose co-transporter type 2 inhibitors -- PPAR-γ Peroxisome proliferator-activated receptor-gamma -- TG triglyceride -- DLAD4U Disease List Automatically Derived For You -- RCSB Research Collaboratory for Structural Bioinformatics; Ethnopharmacology -- Periodicals; Pharmacognosy -- Periodicals; Herbs -- Periodicals; Herbs -- Periodicals; Pharmacognosy -- Periodicals; Pharmacognosie -- Périodiques; Herbes -- Périodiques; 615.1
• DOI: 10.1016/j.jep.2019.112268
• Languages: English
• ISSNs: 0378-8741

Abstract

Abstract: Ethnopharmacological relevance: Phyllanthus emblica Linn. (Syn. Emblica officinalis Gaertn.), has been used to cure many ailments of human beings. Literature survey demonstrates that it has many pharmacological activities i.e. antidiabetic, antioxidant, anti-microbial, antifungal, antiallergic, antiviral, and anticancer properties. Aim of the study: The present study aimed to identify the novel plant-derived antidiabetic compounds from P. emblica to understand the molecular basis of antidiabetic activities. Material and methods: Text mining analysis of P. emblica and its disease association was carried out using server DLAD4U. Due to the highest score of P. emblica with diabetes, the virtual screening of a phytochemical library of P. emblica against three targets of diabetes was carried out. After that FAF-Drug4, admetSAR and DruLiTo servers were used for drug-likeness prediction. Additionally, pharmacophore modeling was also carried out to understand the antidiabetic activity of screened compounds. Results: The docking scores, drug-likeness and pharmacophore studies found that Ellagic acid, Estradiol, Sesamine, Kaempferol, Zeatin, Quercetin, and Leucodelphinidin are potential antidiabetic compounds. Conclusions: Our study shows that phytochemicals of P. emblica are very potential antidiabetic candidates. Using the modern techniques these molecules could be used to develop an effective antidiabetic drugs from a natural resource. Graphical abstract: Image 1