Synthesis and characterization of tannic acid–PEG hydrogel via Mitsunobu polymerization. Issue 3 (9th January 2020)

• Record Type: Journal Article
• Authors: Chen, Chen; Geng, Xi-wen; Pan, Ya-hui; Ma, Yu-ning; Ma, Yu-xia; Gao, Shu-zhong; Huang, Xiao-jun
• Is Part Of: RSC advances. Volume 10:Issue 3(2020)
• Page Start: 1724
• Page End: 1732
• Publication Date: 2020-01-09
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra09229c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Mitsunobu polymerization was involved to construct bulk hydrogel via direct PEGylation of tannic-acid under mild condition. Abstract : Tannic acid (TA) based materials have received significant interest owing to their broad spectrum of chemical and biological properties. Herein, a novel tannic acid based hydrogel, TA–PEG hydrogel, was synthesized via Mitsunobu polymerization/polycondensation, in which TA and polyethylene glycol (PEG) were simply crosslinked together by ether linkages. This method was performed in one pot, straightforward, metal free and robust, ignoring the strong ionic/hydrophobic interactions between tannic acid and PEG. Bearing catechol and pyrogallol units from TA, TA–PEG hydrogel did not only reduce the silver and gold precursor, but also served as a capping agent and stabilizer for the in situ formed Au and Ag nanoparticles (NPs). Furthermore, the antioxidant activity of the hydrogel was excellent (94%) in the case of 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging. TA–PEG hydrogel also showed antibacterial activity against Staphylococcus aureus and Escherichia coli . This work suggested a new method leading to polyphenol based soft materials rather than a complex coacervated microstructure. The resulting TA–PEG hydrogel has potential application in biomedical materials.