Calcium & ROS: Two orchestra directors for the requiem of death. (January 2020)

• Record Type: Journal Article
• Authors: SanMartín, Carol D.; Böhme, Daniela; Rojas-Rivera, Diego
• Is Part Of: Cell calcium. Volume 85(2020)
• Publication Date: 2020-01
• Subjects: TNF -- Mycobacterium tuberculosis -- Calcium -- ROS -- Ryanodine receptor -- Regulated necrosis; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2019.102113
• Languages: English
• ISSNs: 0143-4160

Abstract

Graphical abstract: Highlights: TNF triggers regulated necrosis of mycobacterium-infected macrophages. Mitochondrial reactive oxygen species (mitoROS) are produced in RIPK-1 and RIPK3-dependent way. mitoROS induces lysosomal enzymes activation that lead to BAX activation. BAX triggers ER ryanodine Ca +2 efflux from the endoplasmic reticulum into the mitochondrion. mitoROS and ER ryanodine Ca +2 efflux induces regulated necrosis. Abstract: Tumor necrosis factor alpha (TNF) triggers regulated necrosis of mycobacterium-infected macrophages through of mitochondrial reactive oxygen species (mitoROS) production in a RIPK1/3-dependent manner. To explain that, Roca and colleagues describe an inter-orgallenar circuit which involves the lysosomal ceramide production, mitoROS, BAX activation and RyR Ca 2+ efflux from the endoplasmic reticulum into the mitochondrion.