Olfactory Neuroblastoma: Additional Immunohistochemical Characterization. Issue 5 (29th January 2016)

• Record Type: Journal Article
• Authors: Frierson, Henry F.; Ross, Gary W.; Mills, Stacey E.; Frankfurter, Anthony
• Is Part Of: American journal of clinical pathology. Volume 94:Issue 5(1990)
• Page Start: 547
• Page End: 553
• Publication Date: 2016-01-29
• Subjects: Olfactory neuroblastoma -- Immunohistochemistry -- Neuron-specific enolase -- Intermediate filaments -- S-100 protein -- Tubulin -- Microtubule-associated protein -- Epithelial membrane antigen -- Synaptophysin -- Chromogranin; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; 616.07
• DOI: 10.1093/ajcp/94.5.547
• Languages: English
• ISSNs: 0002-9173

Abstract

Abstract : A panel of 12 antibodies was used to further characterize the immunohistochemical staining profile of olfactory neuroblastoma. The following results were obtained for the 11 neoplasms that were immunostained: neuron-specific enolase 11/11(+), S-100 protein 8/11(+), microtubule-associated protein-2 8/11(+), class III beta-tubulin isotype 9/11(+), neurofilament 200 kD 8/ 11(+), synaptophysin 7/ll(+), glial fibrillary acidic protein 1/ 11(+), chromogranin A 1/11(+), vimentin 1/11(+), keratin (CAM 5.2) 4/11(+), keratin (AEI/AE3) 0/11(+), and epithelial membrane antigen 0/11(+). Expression of two intermediate filaments was found in 4 of the 11 tumors. The authors' data showing that 72% of olfactory neuroblastomas were S-100 protein positive and only one was immunoreactive for glial fibrillary acidic protein agree with other published immunohistochemical studies. With only a single exception, each of the 11 neoplasms was labeled with one or more antibodies that detect neuronal cytoskeletal proteins (class III beta-tubulin isotype, microtubuleassociated protein-2, neurofilament 200 kD). These immunohistochemical results are complementary to the reported electron microscopic findings of intermediate filaments and microtubules in olfactory neuroblastomas.